The aim of this paper is to determine the possibilities of physiotherapy approach in the prevention and treatment of osteoporosis based on a review of the literature. Osteoporosis is a disease characterized by low bone mass and micro architectural deterioration of bone tissue leading to increased bone fragility and a consequent increased risk of fractures. Osteoporosis is more common in women, but it is also possible in men, but in a much smaller percentage. As life expectancy increases, it becomes increasingly challenging in the fight against fracture complications and functional limitations. Factors affecting fracture risk include bone fragility, frequency and severity of falls, and body weight. In order to anticipate the risks of falling and conduct optimal intervention for people with imbalance, it is important to assess the integrity of the underlying physiological systems (sensory, motor, and cognitive). Fractures are associated with significant pain and suffering, disability and even death for affected patients, and significant costs to society. Prevention includes exercise with a diet rich in calcium and vitamin D and various drug therapies. Physiotherapists begin their approach by acting on the principle of the SOAP model. The physiotherapy approach is based on the fact that daily exercise according to age, associated diseases and general status of the patient is necessary while maintaining the intensity and form of exercise at home. Resistance exercises, weight exercises, brisk walking, running, dance activities play a role in the prevention and treatment of osteoporosis.